Molecular logic of cellular diversification in the mouse cerebral cortex.

ABSTRACT: The mammalian cerebral cortex has an unparalleled diversity of cell types, which are generated during development through a series of temporally orchestrated events that are under tight evolutionary constraint and are critical for proper cortical assembly and function^1,2. However, the molecular logic that governs the establishment and organization of cortical cell types remains unknown, largely due to the large number of cell classes that undergo dynamic cell-state transitions over extended developmental timelines. Here we generate a comprehensive atlas of the developing mouse neocortex, using single-cell RNA sequencing and single-cell assay for transposase-accessible chromatin using sequencing. We sampled the neocortex every day throughout embryonic corticogenesis and at early

SUBMITTER: Di Bella DJ 

PROVIDER: S-EPMC9006333 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature