HOX and PBX gene dysregulation as a therapeutic target in glioblastoma multiforme.

ABSTRACT:

Background

Glioblastoma multiforme (GBM) is the most common high-grade malignant brain tumour in adults and arises from the glial cells in the brain. The prognosis of treated GBM remains very poor with 5-year survival rates of 5%, a figure which has not improved over the last few decades. Currently, there is a modest 14-month overall median survival in patients undergoing maximum safe resection plus adjuvant chemoradiotherapy. HOX gene dysregulation is now a widely recognised feature of many malignancies.

Methods

In this study we have focused on HOX gene dysregulation in GBM as a potential therapeutic target in a disease with high unmet need.

Results

We show significant dysregulation of these developmentally crucial genes and specifically that HOX genes A9, A10, C4 an

SUBMITTER: Arunachalam E 

PROVIDER: S-EPMC9006463 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature