Short-term exposure to urban PM_2.5 particles induces histopathological and inflammatory changes in the rat small intestine.

ABSTRACT: Air pollution and exposure to fine airborne particles with aerodynamic diameter <2.5 μm (PM_2.5 ) negatively impacts human health. Airways constitute a primary route of exposure but PM_2.5 -contaminated food, drinks as well as mucociliary and hepatobiliary clearance all constitute potential entry points into the intestine. This study evaluated intestinal histopathological and inflammatory changes as well as enteric neuronal numbers after short- or long-term exposure to urban PM_2.5 . Using a nebulizer, male rats were exposed to a mist with a concentration of 5.3mg PM_2.5 /m³ for 8 h (short term) or 1.8 mg PM_2.5 /m³ for 3 h/day, 5 days/week for 8 weeks (long-term) with controls run in parallel. Samples were taken from

SUBMITTER: Ohlsson L 

PROVIDER: S-EPMC9006536 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature