A serological biomarker of type I collagen degradation is related to a more severe, high neutrophilic, obese asthma subtype.

ABSTRACT:

Background

Asthma is a heterogeneous disease; therefore, biomarkers that can assist in the identification of subtypes and direct therapy are highly desirable. Asthma is a chronic inflammatory disease that leads to changes in the extracellular matrix (ECM) by matrix metalloproteinases (MMPs) degradation causing fragments of type I collagen that is released into circulation.

Objective

Here, we asked if MMP-generated type I collagen (C1M) was associated with subtypes of asthma.

Methods

C1M was serologically assessed at baseline in the adult participants of the All Age Asthma study (ALLIANCE) (n = 233), and in The Prospective Epidemiological Risk Factor study (PERF) (n = 283). In addition, C1M was assessed in mice sensitized to ovalbumin (OVA) and challenged with OVA aero

SUBMITTER: Ronnow SR 

PROVIDER: S-EPMC9006548 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature