Subclinical cardiovascular disease and frailty risk: the atherosclerosis risk in communities study.

ABSTRACT:

Background

Cardiovascular disease (CVD) is associated with a greater frailty risk, but it remains unknown if pathways that contribute to CVD are associated with the frailty risk. Thus, we aimed to investigate whether elevations in high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) for those without known CVD at baseline are associated with a higher frailty risk.

Methods

This study used data from the Atherosclerosis Risk in Communities study. Cardiac biomarkers were measured from stored plasma samples collected at Visit 2 (1991-1993). Frailty was recorded at Visit 5 (2011-2013). Cox regression models were used to determine the association of cardiac biomarkers with frailty risk.

Results

Overall, 360/5199 (6.9%) parti

SUBMITTER: Jia Y 

PROVIDER: S-EPMC9006603 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature