Astrocytes and Microglia Exhibit Cell-Specific Ca²⁺ Signaling Dynamics in the Murine Spinal Cord.

ABSTRACT: The spinal cord is the main pathway connecting brain and peripheral nervous system. Its functionality relies on the orchestrated activity of both neurons and glial cells. To date, most advancement in understanding the spinal cord inner mechanisms has been made either by in vivo exposure of its dorsal surface through laminectomy or by acute ex vivo slice preparation, likely affecting spinal cord physiology in virtue of the necessary extensive manipulation of the spinal cord tissue. This is especially true of cells immediately responding to alterations of the surrounding environment, such as microglia and astrocytes, reacting within seconds or minutes and for up to several days after the original insult. Ca²⁺ signaling is considered one of the most immediate, versati

SUBMITTER: Rieder P 

PROVIDER: S-EPMC9006623 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature