Synaptic loss and progression in mice infected with Angiostrongylus cantonensis in the early stage.

ABSTRACT:

Background

Angiostrongylus cantonensis is also known as rat lungworm. Infection with this parasite is a zoonosis that can cause eosinophilic meningitis and/or eosinophilic meningoencephalitis in humans and may lead to fatal outcomes in severe cases. In this study, we explored the mechanisms of the impairments in the cognitive functions of mice infected with A. cantonensis.

Methods

In infected mice with different infective intensities at different timepoint postinfection, loss and recovery of cognitive functions such as learning and memory abilities were determined. Neuronal death and damage to synaptic structures were analyzed by Western blotting and IHC in infected mice with different infection intensities at different timepoint postinfection.

Results

The results of

SUBMITTER: Jhan KY 

PROVIDER: S-EPMC9006624 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature