Morphine-induced microglial immunosuppression via activation of insufficient mitophagy regulated by NLRX1.

ABSTRACT:

Background

Chronic morphine exposure induces immunosuppression in the peripheral and central nervous system, resulting in susceptibility of patients to invading pathogens. Mitophagy is a crucial regulator of inflammation, and dysregulated mitophagy may cause immunosuppression, but whether mitophagy is linked with morphine-induced immunosuppression in the brain remains unknown. NLRX1 is the only mitochondrially localized NOD family receptor protein which serves as a critical regulator in immunity and mitophagy activation, but it remains an enigma how NLRX1 functions in the crosstalk between microglial inflammatory defense and mitophagy in the presence of morphine.

Methods

Primary microglia and astrocytes, BV2 and MA cell lines were utilized. Mice were stimulated with repeated

SUBMITTER: Peng J 

PROVIDER: S-EPMC9006625 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature