A pooled case-only analysis of obesity and breast cancer subtype among Black women in the southeastern United States.

ABSTRACT:

Purpose

To evaluate the association between obesity and the relative prevalence of tumor subtypes among Black women with breast cancer (BC).

Methods

We conducted a pooled case-only analysis of 1,793 Black women with invasive BC recruited through three existing studies in the southeastern US. Multivariable case-only polytomous logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between obesity, measured by pre-diagnostic body mass index (BMI), and human epidermal growth factor receptor 2 + (HER2 +) and triple negative BC (TNBC) subtype relative to hormone receptor (HR) + /HER2- status (referent).

Results

Among 359 premenopausal women, 55.4% of cases were HR + /HER2 -, 20.1% were HER2 + , and 24.5% we

SUBMITTER: Moore J 

PROVIDER: S-EPMC9006670 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature