Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease.

ABSTRACT:

Background & aims

Non-alcoholic fatty liver disease (NAFLD) is a progressive liver disease with potentially severe complications including cirrhosis and hepatocellular carcinoma. Previously, we have identified circulating lipid signatures associating with liver fat content and non-alcoholic steatohepatitis (NASH). Here, we develop a metabolomic map across the NAFLD spectrum, defining interconnected metabolic signatures of steatosis (non-alcoholic fatty liver, NASH, and fibrosis).

Methods

We performed mass spectrometry analysis of molecular lipids and polar metabolites in serum samples from the European NAFLD Registry patients (n = 627), representing the full spectrum of NAFLD. Using various univariate, multivariate, and machine learning statistical approaches, we interrogate

SUBMITTER: McGlinchey AJ 

PROVIDER: S-EPMC9006858 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature