VP4 Is a Determinant of Alpha-Defensin Modulation of Rotaviral Infection.

ABSTRACT: Fecal-oral pathogens encounter constitutively expressed enteric alpha-defensins in the intestine during replication and transmission. Alpha-defensins can be potently antiviral and antibacterial; however, their primary sequences, the number of isoforms, and their activity against specific microorganisms often vary greatly between species, reflecting adaptation to species-specific pathogens. Therefore, alpha-defensins might influence not only microbial evolution and tissue tropism within a host but also species tropism and zoonotic potential. To investigate these concepts, we generated a panel of enteric and myeloid alpha-defensins from humans, rhesus macaques, and mice and tested their activity against group A rotaviruses, an important enteric viral pathogen of humans and animals. Rotaviral

SUBMITTER: Hu CT 

PROVIDER: S-EPMC9006894 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature