PPRV-Induced Autophagy Facilitates Infectious Virus Transmission by the Exosomal Pathway.

ABSTRACT: Peste des petits ruminants virus (PPRV) is an important pathogen that seriously influences the productivity of small ruminants worldwide. We showed previously that PPRV induced sustained autophagy for their replication in host cells. Many studies have shown that exosomes released from virus-infected cells contain a variety of viral and host cellular factors that are able to modulate the recipient's cellular response and result in productive infection of the recipient host. Here, we show that PPRV infection results in packaging of the viral genomic RNA and partial viral proteins into exosomes of Vero cells and upregulates exosome secretion. We provide evidence showing that the exosomal viral cargo can be transferred to and establish productive infection in a new target cell. Importantly, ou

SUBMITTER: Wan Y 

PROVIDER: S-EPMC9006942 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature