A caged imidazopyrazinone for selective bioluminescence detection of labile extracellular copper(ii).

ABSTRACT: Copper is an essential redox-active metal that plays integral roles in biology ranging from enzymatic catalysis to mitochondrial respiration. However, if not adequately regulated, this redox activity has the potential to cause oxidative stress through the production of reactive oxygen species. Indeed, the dysregulation of copper has been associated with a variety of disease states including diabetes, neurodegenerative disorders, and multiple cancers. While increasing tools are being developed for illuminating labile intracellular copper pools and the trafficking pathways in which they are involved, significantly less attention has been given to the analogous extracellular labile pool. To address this gap, we have developed a bioluminescence-based imaging probe, picolinic ester caged-diphen

SUBMITTER: O'Sullivan JJ 

PROVIDER: S-EPMC9006956 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature