Whole-brain 3D mapping of oxygen metabolism using constrained quantitative BOLD.

ABSTRACT: Quantitative BOLD (qBOLD) MRI permits noninvasive evaluation of hemodynamic and metabolic states of the brain by quantifying parametric maps of deoxygenated blood volume (DBV) and hemoglobin oxygen saturation level of venous blood (Y_v), and along with a measurement of cerebral blood flow (CBF), the cerebral metabolic rate of oxygen (CMRO₂). The method, thus should have potential to provide important information on many neurological disorders as well as normal cerebral physiology. One major challenge in qBOLD is to separate deoxyhemoglobin's contribution to R₂' from other sources modulating the voxel signal, for instance, R₂, R₂' from non-heme iron (R'_2,nh), and macroscopic magnetic field variations. Further, even with succes

SUBMITTER: Lee H 

PROVIDER: S-EPMC9007034 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature