Foscarnet-Type Inorganic-Organic Hybrid Nanoparticles for Effective Antiviral Therapy.

ABSTRACT: [ZrO]²⁺[(FCN)_0.4(OH)_0.8]^2- and Gd³⁺[FCN]^3- inorganic-organic hybrid nanoparticles (IOH-NPs) are novel saline antiviral nanocarriers with foscarnet (FCN) as a drug anion. FCN as a pyrophosphate analogue serves as a prototype of a viral DNA polymerase inhibitor. FCN is used for the treatment of herpesvirus infections, including the drug-resistant cytomegalovirus (CMV) and herpes simplex viruses, HSV-1 and HSV-2. The novel [ZrO]²⁺[(FCN)_0.4(OH)_0.8]^2- and Gd³⁺[FCN]^3- IOH-NPs are characterized by aqueous synthesis, small size (20-30 nm), low material complexity, high biocompatibility, and high drug load (up to 44 wt % FCN per nanoparticle). The antiviral activity of

SUBMITTER: Khorenko M 

PROVIDER: S-EPMC9007112 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature