Investigation of Neural Substrates of Erroneous Behavior in a Delayed-Response Task.

ABSTRACT: Motor cortical neurons exhibit persistent selective activities (selectivity) during motor planning. Experimental perturbation of selectivity results in the failure of short-term memory retention and consequent behavioral biases, demonstrating selectivity as a neural characteristic of encoding previous sensory input or future action. However, even without experimental manipulation, animals occasionally fail to maintain short-term memory leading to erroneous choice. Here, we investigated neural substrates that lead to the incorrect formation of selectivity during short-term memory. We analyzed neuronal activities in anterior lateral motor cortex (ALM) of mice, a region known to be engaged in motor planning while mice performed the tactile delayed-response task. We found that highly selective

SUBMITTER: Chae S 

PROVIDER: S-EPMC9007410 | biostudies-literature | 2022 Mar-Apr

REPOSITORIES: biostudies-literature