Modeling Diffusive Mixing in Antisolvent Crystallization.

ABSTRACT: Diffusion controls local concentration profiles at interfaces between segregated fluid elements during mixing processes. This is important for antisolvent crystallization, where it is intuitively argued that local concentration profiles at interfaces between solution and antisolvent fluid elements can result in significant supersaturation overshoots over and above that at the final mixture composition, leading to poorly controlled nucleation. Previous work on modeling diffusive mixing in antisolvent crystallization has relied on Fickian diffusion, where concentration gradients are the driving force for diffusion. This predicts large overshoots in the supersaturation at interfaces between solution and antisolvent, as is often intuitively expected. However, chemical potential gradients provi

SUBMITTER: Miller R 

PROVIDER: S-EPMC9007412 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature