An efficient and robust approach to Mendelian randomization with measured pleiotropic effects in a high-dimensional setting.

ABSTRACT: Valid estimation of a causal effect using instrumental variables requires that all of the instruments are independent of the outcome conditional on the risk factor of interest and any confounders. In Mendelian randomization studies with large numbers of genetic variants used as instruments, it is unlikely that this condition will be met. Any given genetic variant could be associated with a large number of traits, all of which represent potential pathways to the outcome which bypass the risk factor of interest. Such pleiotropy can be accounted for using standard multivariable Mendelian randomization with all possible pleiotropic traits included as covariates. However, the estimator obtained in this way will be inefficient if some of the covariates do not truly sit on pleiotropic pathways to

SUBMITTER: Grant AJ 

PROVIDER: S-EPMC9007434 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature