Paired Simulations and Experimental Investigations into the Calcium-Dependent Conformation of Albumin.

ABSTRACT: Serum albumin is the most abundant protein in blood plasma, and it is involved in multiple biological processes. Serum albumin has recently been adapted for improving biomaterial integration with bone tissue, and studies have shown the importance of this protein in bone repair and regeneration. However, the mechanism of action is not yet clear. In stark contrast, other studies have demonstrated that albumin blocks cell adhesion to surfaces, which is seen as a limitation to its bone healing role. These apparent contradictions suggest that the conformation of albumin facilitates its bioactivity, leading to enhanced bone repair. Serum albumin is known to play a major role in maintaining the calcium ion concentration in blood plasma. Due to the prevalence of calcium at bone repair and regenera

SUBMITTER: Patel D 

PROVIDER: S-EPMC9007495 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature