KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis.

ABSTRACT: Epigenetic regulation plays extensive roles in diseases and development. Disruption of epigenetic regulation not only increases the risk of cancer, but can also cause various developmental defects. However, the question of how epigenetic changes lead to tissue-specific responses during neural crest fate determination and differentiation remains understudied. Using palatogenesis as a model, we reveal the functional significance of Kdm6b, an H3K27me3 demethylase, in regulating mouse embryonic development. Our study shows that Kdm6b plays an essential role in cranial neural crest development, and loss of Kdm6b disturbs P53 pathway-mediated activity, leading to complete cleft palate along with cell proliferation and differentiation defects in mice. Furthermore, activity of

SUBMITTER: Guo T 

PROVIDER: S-EPMC9007587 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature