Intraoperative High Fraction of Inspiratory Oxygen is Independently Associated with Worse Outcome After Living-Donor Liver Transplantation: A Retrospective Study.

ABSTRACT:

Background

Ischemia and reperfusion injury is an important factor that determines graft function after liver transplantation, and oxygen plays a crucial role in this process. However, the relationship between the intraoperative high fraction of inspiratory oxygen (FiO₂) and living-donor-liver-transplantation (LDLT) outcome remains unclear.

Patients and methods

A total of 199 primary adult-to-adult LDLT cases in Kyoto University Hospital between January 2010 and December 2017 were enrolled in this study. The intraoperative FiO₂ was averaged using the total amount of intraoperative oxygen and air and defined as the calculated FiO₂ (cFiO₂). The cutoff value of cFiO₂ was set at 0.5.

Results

Between the cFiO₂

SUBMITTER: Miyachi Y 

PROVIDER: S-EPMC9007621 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature