Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death.

ABSTRACT:

Objective

To determine whether the duration of noninvasive respiratory support exposure is associated with bronchopulmonary dysplasia (BPD) or death in preterm infants.

Methods

Multicenter, retrospective study of infants born at <29 weeks' gestation. The association between days on noninvasive respiratory support and BPD or death was determined using instrumental variable techniques and generalized propensity score matching to account for potential confounding by illness severity.

Results

Among 6268 infants 36% developed BPD or died. The median duration of noninvasive respiratory support was 18 days. There was inconsistency in the association between noninvasive support and BPD or death when analyzed by instrumental variable techniques (Average Marginal Effect -0.37;

SUBMITTER: Gentle SJ 

PROVIDER: S-EPMC9007818 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature