Dataset Information

Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death.

ABSTRACT:

Objective

To determine whether the duration of noninvasive respiratory support exposure is associated with bronchopulmonary dysplasia (BPD) or death in preterm infants.

Methods

Multicenter, retrospective study of infants born at <29 weeks' gestation. The association between days on noninvasive respiratory support and BPD or death was determined using instrumental variable techniques and generalized propensity score matching to account for potential confounding by illness severity.

Results

Among 6268 infants 36% developed BPD or died. The median duration of noninvasive respiratory support was 18 days. There was inconsistency in the association between noninvasive support and BPD or death when analyzed by instrumental variable techniques (Average Marginal Effect -0.37; 95% CI -1.23 to 0.50) and generalized propensity score matching (Average Marginal Effect 0.46; 95% CI 0.33 to 0.60).

Conclusion

Findings on the association between duration of exposure to noninvasive respiratory support and the development of BPD or death were inconclusive.

Clinicaltrials

Gov id

Generic Database:NCT00063063.

SUBMITTER: Gentle SJ

PROVIDER: S-EPMC9007818 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Publications

Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death.

Gentle Samuel J SJ Carper Benjamin B Laughon Matthew M MM Jensen Erik A EA Williams Austin A Travers Colm P CP Ambalavanan Namasivayam N Lal Charitharth V CV Carlo Waldemar A WA

Journal of perinatology : official journal of the California Perinatal Association 20220115 4

<h4>Objective</h4>To determine whether the duration of noninvasive respiratory support exposure is associated with bronchopulmonary dysplasia (BPD) or death in preterm infants.<h4>Methods</h4>Multicenter, retrospective study of infants born at <29 weeks' gestation. The association between days on noninvasive respiratory support and BPD or death was determined using instrumental variable techniques and generalized propensity score matching to account for potential confounding by illness severity. ...[more]

PMID: 35034096

Similar Datasets

Project description:BackgroundWith the advances in neonatal intensive care, the survival rate of extremely preterm infants is increasing. However, bronchopulmonary dysplasia (BPD) remains a major cause of morbidity among infants in this group. This study examined the changes in respiratory support modalities, specifically heated humidified high-flow nasal cannula (HHHFNC), and their association with BPD incidence among preterm infants born at < 29 weeks of gestation.MethodThis population-based retrospective cohort study included infants born at < 29 weeks of gestation between 2016 and 2020. Data regarding the use and duration of respiratory support modalities were obtained, including mechanical ventilation, continuous positive airway pressure, HHHFNC, and low-flow oxygen therapy. Additionally, the incidence of BPD was determined in the included infants. Trend analysis for each respiratory support modality and BPD incidence rate was performed to define the temporal changes associated with changes in BPD rates. In addition, a logistic regression model was developed to identify the association between BPD and severity grade using HHHFNC.ResultsThree Hundred and sixteen infants were included in this study. The use and duration of HHHFNC therapy increased during the study period. Throughout the study period, the overall incidence of BPD was 49%, with no significant trends. The BPD rate was significantly higher in the infants who received HHHFNC than in those who did not (52% vs. 39%, P = 0.03). Analysis of BPD severity grades showed that both grade 1 BPD (34% vs. 21%, P = 0.03) and grade 2 BPD (12% vs. 1%, P < 0.01) were significantly more common among infants who received HHHFNC than among those who did not. In contrast, the incidence of grade 3 BPD was lower in infants who received HHFNC (6% vs. 17%, P < 0.01). The duration in days of HHHFNC was found to significantly predict BPD incidence (OR 1.04 [95%CI: 1.01-1.06], P < 0.01) after adjusting for confounding variables.ConclusionThe use of HHHFNC in extremely preterm infants born at < 29 weeks of gestation is increasing. There was a significant association between the duration of HHHFNC therapy and the development of BPD in extremely preterm infants born at < 29 weeks of gestation.

Dataset Information

Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death.

Objective

Methods

Results

Conclusion

Clinicaltrials

Gov id

Publications

Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death.

Similar Datasets

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