Sex-based disparities in outcome in pediatric acute lymphoblastic leukemia: a Children's Oncology Group report.

ABSTRACT:

Background

Boys with acute lymphoblastic leukemia (ALL) have historically experienced inferior survival compared to girls. This study determined whether sex-based disparities persist with contemporary therapy and whether patterns of treatment failure vary by sex.

Methods

Patients 1 to 30.99 years old were enrolled on frontline Children's Oncology Group trials between 2004 and 2014. Boys received an additional year of maintenance therapy. Sex-based differences in the distribution of various prognosticators, event-free survival (EFS) and overall survival (OS), and subcategories of relapse by site were explored.

Results

A total of 8202 (54.4% male) B-cell ALL (B-ALL) and 1562 (74.3% male) T-cell ALL (T-ALL) patients were included. There was no sex-based difference in cen

SUBMITTER: Gupta S 

PROVIDER: S-EPMC9007837 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature