Four-dimensional computed tomography of the left ventricle, Part II: Estimation of mechanical activation times.

ABSTRACT:

Purpose

We demonstrate the viability of a four-dimensional X-ray computed tomography (4DCT) imaging system to accurately and precisely estimate mechanical activation times of left ventricular (LV) wall motion. Accurate and reproducible timing estimates of LV wall motion may be beneficial in the successful planning and management of cardiac resynchronization therapy (CRT).

Methods

We developed an anthropomorphically accurate in silico LV phantom based on human CT images with programmed septal-lateral wall dyssynchrony. Twenty-six temporal phases of the in silico phantom were used to sample the cardiac cycle of 1 s. For each of the 26 phases, 1 cm thick axial slabs emulating axial CT image volumes were extracted, 3D printed, and imaged using a commercially available CT scanner

SUBMITTER: Manohar A 

PROVIDER: S-EPMC9007845 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature