Effects of T₂ * on accuracy and precision of dynamic T₁ measurements using the single reference variable flip angle method: a simulation study.

ABSTRACT:

Purpose

To study in simulation and in theory the accuracy and precision of dynamic T₁ measurements obtained using the previously published single-reference variable flip angle (SR-VFA) technique, with a focus on the effects of dynamic changes in T₂ * on the calculation.

Methods

Monte Carlo simulations were performed over 1000 noisy iterations for the VFA method, the SR-VFA method, and a proposed method, SR-VFA with a T₂ * correction (SR-VFA-T₂ *). Dynamic T₁ estimates were calculated analytically for each method, with signals modeled by the steady-state spoiled gradient echo equation. The mean and standard deviation of these estimates were calculated and compared to truth, while varying repetition time (TR), baseline and

SUBMITTER: Malmberg MA 

PROVIDER: S-EPMC9007881 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature