Fetal Brain Volume Predicts Neurodevelopment in Congenital Heart Disease.

ABSTRACT:

Background

Neurodevelopmental impairment is common in children with congenital heart disease (CHD), but postnatal variables explain only 30% of the variance in outcomes. To explore whether the antecedents for neurodevelopmental disabilities might begin in utero, we analyzed whether fetal brain volume predicted subsequent neurodevelopmental outcome in children with CHD.

Methods

Fetuses with isolated CHD and sociodemographically comparable healthy control fetuses underwent fetal brain magnetic resonance imaging and 2-year neurodevelopmental evaluation with the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III) and the Adaptive Behavior Assessment System, Third Edition (ABAS-3). Hierarchical regression evaluated potential predictors of Bayley-III and AB

SUBMITTER: Sadhwani A 

PROVIDER: S-EPMC9007882 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature