Diverse operant control of different motor cortex populations during learning.

ABSTRACT: During motor learning,¹ as well as during neuroprosthetic learning,^2-4 animals learn to control motor cortex activity in order to generate behavior. Two different populations of motor cortex neurons, intra-telencephalic (IT) and pyramidal tract (PT) neurons, convey the resulting cortical signals within and outside the telencephalon. Although a large amount of evidence demonstrates contrasting functional organization among both populations,^5,6 it is unclear whether the brain can equally learn to control the activity of either class of motor cortex neurons. To answer this question, we used a calcium-imaging-based brain-machine interface (CaBMI)³ and trained different groups of mice to modulate the activity of either IT or PT n

SUBMITTER: Vendrell-Llopis N 

PROVIDER: S-EPMC9007898 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature