Genetic context of oncogenic drivers dictates vascular sarcoma development in aP2-Cre mice.

ABSTRACT: Angiosarcomas are aggressive vascular sarcomas that arise from endothelial cells and have an extremely poor prognosis. Because of the rarity of angiosarcomas, knowledge of molecular drivers and optimized treatment strategies is lacking, highlighting the need for in vivo models to study the disease. Previously, we generated genetically engineered mouse models of angiosarcoma driven by aP2-Cre-mediated biallelic loss of Dicer1 or conditional activation of Kras^G12D with Cdkn2a loss that histologically and genetically resemble human tumors. In the present study, we found that DICER1 functions as a potent tumor suppressor and its deletion, in combination with either KRAS^G12D expression or Cdkn2a loss, is associated with angiosarcoma development. Independent of the genetic

SUBMITTER: Hanna JA 

PROVIDER: S-EPMC9007915 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature