Systematically evaluating DOTATATE and FDG as PET immuno-imaging tracers of cardiovascular inflammation.

ABSTRACT: In recent years, cardiovascular immuno-imaging by positron emission tomography (PET) has undergone tremendous progress in preclinical settings. Clinically, two approved PET tracers hold great potential for inflammation imaging in cardiovascular patients, namely FDG and DOTATATE. While the former is a widely applied metabolic tracer, DOTATATE is a relatively new PET tracer targeting the somatostatin receptor 2 (SST2). In the current study, we performed a detailed, head-to-head comparison of DOTATATE-based radiotracers and [¹⁸F]F-FDG in mouse and rabbit models of cardiovascular inflammation. For mouse experiments, we labeled DOTATATE with the long-lived isotope [⁶⁴Cu]Cu to enable studying the tracer's mode of action by complementing in vivo PET/CT experiments with thoro

SUBMITTER: Toner YC 

PROVIDER: S-EPMC9007951 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature