Nuclear translocation of p85β promotes tumorigenesis of PIK3CA helical domain mutant cancer.
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ABSTRACT:
SUBMITTER: Hao Y
PROVIDER: S-EPMC9007954 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Publications
Nuclear translocation of p85β promotes tumorigenesis of PIK3CA helical domain mutant cancer.
Hao Yujun Y He Baoyu B Wu Liping L Li Yamu Y Wang Chao C Wang Ting T Sun Longci L Zhang Yanhua Y Zhan Yangyang Y Zhao Yiqing Y Markowitz Sanford S Veigl Martina M Conlon Ronald A RA Wang Zhenghe Z
Nature communications 20220413 1
PI3Ks consist of p110 catalytic subunits and p85 regulatory subunits. PIK3CA, encoding p110α, is frequently mutated in human cancers. Most PIK3CA mutations are clustered in the helical domain or the kinase domain. Here, we report that p85β disassociates from p110α helical domain mutant protein and translocates into the nucleus through a nuclear localization sequence (NLS). Nuclear p85β recruits deubiquitinase USP7 to stabilize EZH1 and EZH2 and enhances H3K27 trimethylation. Knockout of p85β or ...[more]
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