MiR-92a/KLF4/p110δ regulates titanium particles-induced macrophages inflammation and osteolysis.

ABSTRACT: As total joint replacement is widely applied for severe arthropathy, peri-prosthetic aseptic loosening as one of the main causes of implant failure has drawn wide attention. Wear particles such as titanium particles (TiPs) derived from prosthesis can initiate macrophages inflammation and sequentially activate osteoclasts, which results in bone resorption and osteolysis for long-term. Therefore, inhibiting wear particles induced macrophages inflammation is considered as a promising therapy for AL. In this research, we found that the inhibition of p110δ, a member of class IA PI3Ks family, could significantly dampen the TiPs-induced secretion of TNFα and IL-6. By the transfection of siRNA targeting p110δ, we confirmed that p110δ was responsible for TNFα and IL-6 trafficking out of Golgi compl

SUBMITTER: Wen Z 

PROVIDER: S-EPMC9007998 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature