A subpopulation of cortical VIP-expressing interneurons with highly dynamic spines.

ABSTRACT: Structural synaptic plasticity may underlie experience and learning-dependent changes in cortical circuits. In contrast to excitatory pyramidal neurons, insight into the structural plasticity of inhibitory neurons remains limited. Interneurons are divided into various subclasses, each with specialized functions in cortical circuits. Further knowledge of subclass-specific structural plasticity of interneurons is crucial to gaining a complete mechanistic understanding of their contribution to cortical plasticity overall. Here, we describe a subpopulation of superficial cortical multipolar interneurons expressing vasoactive intestinal peptide (VIP) with high spine densities on their dendrites located in layer (L) 1, and with the electrophysiological characteristics of bursting cells. Using lo

SUBMITTER: Georgiou C 

PROVIDER: S-EPMC9008030 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature