Beneficial ex vivo immunomodulatory and clinical effects of clarithromycin in COVID-19.

ABSTRACT:

Introduction

Macrolide antibiotics have immunomodulatory properties which may be beneficial in viral infections. However, the precise effects of macrolides on T cell responses to COVID, differences between different macrolides, and synergistic effects with other antibiotics have not been explored.

Methods

We investigated the effect of antibiotics (amoxicillin, azithromycin, clarithromycin, and combined amoxicillin with clarithromycin) on lymphocyte intracellular cytokine levels and monocyte phagocytosis in healthy volunteer PBMCs stimulated ex vivo with SARS-CoV-2 S1+2 spike protein. A retrospective cohort study was performed on intensive care COVID-19 patients.

Results

Co-incubation of clarithromycin with spike protein-stimulated healthy volunteer PBMCs ex vivo resul

SUBMITTER: Snow TAC 

PROVIDER: S-EPMC9008033 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature