Protection following BNT162b2 booster in adolescents substantially exceeds that of a fresh 2-dose vaccine.

ABSTRACT: Israel began administering a BNT162b2 booster dose to restore protection following the waning of the 2-dose vaccine. Biological studies have shown that a "fresh" booster dose leads to increased antibody levels compared to a fresh 2-dose vaccine, which may suggest increased effectiveness. To compare the real-world effectiveness of a fresh (up to 60 days) booster dose with that of a fresh 2-dose vaccine, we took advantage of a quasi-experimental study that compares populations that were eligible to receive the vaccine at different times due to age-dependent policies. Specifically, we compared the confirmed infection rates in adolescents aged 12-14 (215,653 individuals) who received the 2-dose vaccine and in adolescents aged 16-18 (103,454 individuals) who received the booster dose. Our analy

SUBMITTER: Amir O 

PROVIDER: S-EPMC9008037 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature