Structure of the active pharmaceutical ingredient bismuth subsalicylate.

ABSTRACT: Structure determination of pharmaceutical compounds is invaluable for drug development but remains challenging for those that form as small crystals with defects. Bismuth subsalicylate, among the most commercially significant bismuth compounds, is an active ingredient in over-the-counter medications such as Pepto-Bismol, used to treat dyspepsia and H. pylori infections. Despite its century-long history, the structure of bismuth subsalicylate is still under debate. Here we show that advanced electron microscopy techniques, namely three-dimensional electron diffraction and scanning transmission electron microscopy, can give insight into the structure of active pharmaceutical ingredients that are difficult to characterize using conventional methods due to their small size or intricate structu

SUBMITTER: Svensson Grape E 

PROVIDER: S-EPMC9008038 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature