Bone strength and composition in spacefaring rodents: systematic review and meta-analysis.

ABSTRACT: Studying the effects of space travel on bone of experimental animals provides unique advantages, including the ability to perform post-mortem analysis and mechanical testing. To synthesize the available data to assess how much and how consistently bone strength and composition parameters are affected by spaceflight, we systematically identified studies reporting bone health in spacefaring animals from Medline, Embase, Web of Science, BIOSIS, and NASA Technical reports. Previously, we reported the effect of spaceflight on bone architecture and turnover in rodents and primates. For this study, we selected 28 articles reporting bone strength and composition in 60 rats and 60 mice from 17 space missions ranging from 7 to 33 days in duration. Whole bone mechanical indices were significantly dec

SUBMITTER: Goldsmith M 

PROVIDER: S-EPMC9008045 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature