Metabolomic differences in lung function metrics: evidence from two cohorts.

ABSTRACT:

Rationale

The biochemical mechanisms underlying lung function are incompletely understood.

Objectives

To identify and validate the plasma metabolome of lung function using two independent adult cohorts: discovery-the European Prospective Investigation into Cancer-Norfolk (EPIC-Norfolk, n=10 460) and validation-the VA Normative Aging Study (NAS) metabolomic cohort (n=437).

Methods

We ran linear regression models for 693 metabolites to identify associations with forced expiratory volume in one second (FEV₁) and the ratio of FEV₁ to forced vital capacity (FEV₁/FVC), in EPIC-Norfolk then validated significant findings in NAS. Significance in EPIC-Norfolk was denoted using an effective number of tests threshold of 95%; a metabolite was cons

SUBMITTER: Kelly RS 

PROVIDER: S-EPMC9008068 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature