Development of Thalamocortical Structural Connectivity in Typically Developing and Psychosis Spectrum Youths.

ABSTRACT:

Background

Thalamocortical white matter connectivity is disrupted in psychosis and is hypothesized to play a role in its etiology and associated cognitive impairment. Attenuated cognitive symptoms often begin in adolescence, during a critical phase of white matter and cognitive development. However, little is known about the development of thalamocortical white matter connectivity and its association with cognition.

Methods

This study characterized effects of age, sex, psychosis symptomatology, and cognition in thalamocortical networks in a large sample of youths (N = 1144, ages 8-22 years, 46% male) from the Philadelphia Neurodevelopmental Cohort, which included 316 typically developing youths, 330 youths on the psychosis spectrum, and 498 youths with other psychopathology.

SUBMITTER: Avery SN 

PROVIDER: S-EPMC9008075 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature