Dynamic impact of virome on colitis and colorectal cancer: Immunity, inflammation, prevention and treatment.

ABSTRACT: The gut microbiome includes a series of microorganism genomes, such as bacteriome, virome, mycobiome, etc. The gut microbiota is critically involved in intestine immunity and diseases, including inflammatory bowel disease (IBD) and colorectal cancer (CRC); however, the underlying mechanism remains incompletely understood. Clarifying the relationship between microbiota and inflammation may profoundly improve our understanding of etiology, disease progression, patient management, and the development of prevention and treatment. In this review, we discuss the latest studies of the influence of enteric viruses (i.e., commensal viruses, pathogenic viruses, and bacteriophages) in the initiation, progression, and complication of colitis and colorectal cancer, and their potential for novel prevent

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9008076 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature