Harmonization of [¹¹C]raclopride brain PET images from the HR+ and HRRT: method development and validation in human subjects.

ABSTRACT:

Background

There has been an ongoing need to compare and combine the results of new PET imaging studies conducted with [¹¹C]raclopride with older data. This typically means harmonizing data across different scanners. Previous harmonization studies have utilized either phantoms or human subjects, but the use of both phantoms and humans in one harmonization study is not common. The purpose herein was (1) to use phantom images to develop an inter-scanner harmonization technique and (2) to test the harmonization technique in human subjects.

Methods

To develop the harmonization technique (Experiment 1), the Iida brain phantom was filled with F-18 solution and scanned on the two scanners in question (HRRT, HR+, Siemens/CTI). Phantom images were used to determine the opt

SUBMITTER: Hoye J 

PROVIDER: S-EPMC9008103 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature