Algorithmic multiscale analysis for the FcRn mediated regulation of antibody PK in human.

ABSTRACT: A demonstration is provided on how algorithmic asymptotic analysis of multi-scale pharmacokinetics (PK) systems can provide (1) system level understanding and (2) predictions on the response of the model when parameters vary. Being algorithmic, this type of analysis is not hindered by the size or complexity of the model and requires no input from the investigator. The algorithm identifies the constraints that are generated by the fast part of the model and the components of the slow part of the model that drive the system within these constraints. The demonstration is based on a typical monoclonal antibody PK model. It is shown that the findings produced by the traditional methodologies, which require significant input by the investigator, can be produced algorithmically and more accuratel

SUBMITTER: Patsatzis DG 

PROVIDER: S-EPMC9008124 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature