Expression of circadian clock genes in leukocytes of patients with Meniere's disease.

ABSTRACT:

Objectives

The underlying etiology of Meniere's disease (MD) is not completely clear, but the precipitated triggers may alter the circadian clock in patients with MD. This study aims to survey the expression of circadian clock genes in peripheral blood (PB) leukocytes of MD patients.

Methods

We investigated the expression of nine circadian clock genes in the PB leukocytes of patients with MD and normal controls using real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR).

Results

We observed significantly lower expression of PER1 gene and higher expression of CLOCK gene in MD patients than those in normal controls (p < 0.05). PER1 did not associate with the degree of dizziness handicap in the patients with MD, but

SUBMITTER: Yang CH 

PROVIDER: S-EPMC9008173 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature