Gut Microbiome Signature Are Correlated With Bone Mineral Density Alterations in the Chinese Elders.

ABSTRACT:

Objective

Osteoporosis (OP), clinically featured with a low bone mineral density (BMD) and high risk of bone fracture, has become a major risk factor of disability and death in the elders, especially in postmenopausal women. The gut microbiome (GM) is thought to be implicated in bone metabolism. Herein, we clarified the composition signature and gene functional profile of GM in older people with normal and low BMD.

Design and methods

A total of 455 participants underwent the BMD measurement and biochemical detection. GM analysis was further performed on 113 cases of postmenopausal women and men aged over 50, including both 16S rRNA and metagenomic sequencing.

Results

Generally, the BMD value was significantly lower in the older age groups, especially in the postmenopa

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9008261 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature