Risk Factors for Pulmonary Air Leak and Clinical Prognosis in Patients With COVID-19 Related Acute Respiratory Failure: A Retrospective Matched Control Study.

ABSTRACT:

Background

The role of excessive inspiratory effort in promoting alveolar and pleural rupture resulting in air leak (AL) in patients with SARS-CoV-2 induced acute respiratory failure (ARF) while on spontaneous breathing is undetermined.

Methods

Among all patients with COVID-19 related ARF admitted to a respiratory intensive care unit (RICU) and receiving non-invasive respiratory support, those developing an AL were and matched 1:1 [by means of PaO2/FiO2 ratio, age, body mass index-BMI and subsequent organ failure assessment (SOFA)] with a comparable population who did not (NAL group). Esophageal pressure (ΔP_es) and dynamic transpulmonary pressure (ΔP_L) swings were compared between groups. Risk factors affecting AL onset were evaluated. The composite out

SUBMITTER: Tonelli R 

PROVIDER: S-EPMC9008271 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature