Potential Involvement of Complement Activation in Kidney Vascular Lesions of Arterionephrosclerosis.

ABSTRACT:

Background

Complement dysregulation has been implicated in the pathogenesis of malignant nephrosclerosis with typical pathological manifestation as thrombotic microangiopathy (TMA) in recent studies. The aim of the present study was to evaluate the potential role of complement activation in arterionephrosclerosis, the major pathological change in benign hypertensive nephrosclerosis.

Methods

Patients with biopsy-proven arterionephrosclerosis from 2010 to 2018 in our center were retrospectively enrolled in the present study. The clinical data were retrieved from the medical chart record. The pathological changes of renal biopsy were semiquantitatively evaluated. The ratio of inner-/outer-luminal diameter of the arterioles was calculated to evaluate the degree of arterioscleros

SUBMITTER: Chen X 

PROVIDER: S-EPMC9008485 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature