Co-expression analysis to identify key modules and hub genes associated with COVID-19 in platelets.

ABSTRACT: Corona virus disease 2019 (COVID-19) increases the risk of cardiovascular occlusive/thrombotic events and is linked to poor outcomes. The underlying pathophysiological processes are complex, and remain poorly understood. To this end, platelets play important roles in regulating the cardiovascular system, including via contributions to coagulation and inflammation. There is ample evidence that circulating platelets are activated in COVID-19 patients, which is a primary driver of the observed thrombotic outcome. However, the comprehensive molecular basis of platelet activation in COVID-19 disease remains elusive, which warrants more investigation. Hence, we employed gene co-expression network analysis combined with pathways enrichment analysis to further investigate the aforementioned issues

SUBMITTER: Alarabi AB 

PROVIDER: S-EPMC9008611 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature