A Novel Defined Pyroptosis-Related Gene Signature for Predicting Prognosis and Treatment of Glioma.

ABSTRACT: Pyroptosis, a form of programmed cell death, that plays a significant role in the occurrence and progression of tumors, has been frequently investigated recently. However, the prognostic significance and therapeutic value of pyroptosis in glioma remain undetermined. In this research, we revealed the relationship of pyroptosis-related genes to glioma by analyzing whole transcriptome data from The Cancer Genome Atlas (TCGA) dataset serving as the training set and the Chinese Glioma Genome Atlas (CGGA) dataset serving as the validation set. We identified two subgroups of glioma patients with disparate prognostic and clinical features by performing consensus clustering analysis on nineteen pyroptosis-related genes that were differentially expressed between glioma and normal brain tissues. We f

SUBMITTER: Yang Z 

PROVIDER: S-EPMC9008739 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature