Second Heart Field-Derived Cells Contribute to Angiotensin II-Mediated Ascending Aortopathies.

ABSTRACT:

Background

The ascending aorta is a common location for aneurysm and dissection. This aortic region is populated by a mosaic of medial and adventitial cells that are embryonically derived from either the second heart field (SHF) or the cardiac neural crest. SHF-derived cells populate areas that coincide with the spatial specificity of thoracic aortopathies. The purpose of this study was to determine whether and how SHF-derived cells contribute to ascending aortopathies.

Methods

Ascending aortic pathologies were examined in patients with sporadic thoracic aortopathies and angiotensin II (AngII)-infused mice. Ascending aortas without overt pathology from AngII-infused mice were subjected to mass spectrometry-assisted proteomics and molecular features of SHF-derived cells were

SUBMITTER: Sawada H 

PROVIDER: S-EPMC9008740 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature