Parental metal exposures as potential risk factors for spina bifida in Bangladesh.

ABSTRACT:

Background

Neural tube defects are a pressing public health concern despite advances in prevention from folic acid-based strategies. Numerous chemicals, in particular arsenic, have been associated with neural tube defects in animal models and could influence risk in humans.

Objectives

We investigated the relationship between parental exposure to arsenic and 17 metals and risk of neural tube defects (myelomeningocele and meningocele) in a case control study in Bangladesh.

Methods

Exposure assessment included analysis of maternal and paternal toenail samples using inductively coupled plasma mass spectrometry (ICP-MS). A total of 278 participants (155 cases and 123 controls) with data collected from 2016 to 2020 were included in the analysis.

Results

In the patern

SUBMITTER: Tindula G 

PROVIDER: S-EPMC9008873 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature