Addiction of High Dose of Benzodiazepine: Verona Detox Approach With Flumazenil.

ABSTRACT:

Introduction

Since the 1990s there has been evidence of the significant role Flumazenil (FLU) has in benzodiazepines (BZD) detoxes. The Verona Detox approach has been developed for high dose BZD and Z-drug detoxification via continuous subcutaneous infusion of FLU, a selective BZD receptor antagonist acting on the BZD subunit of the GABA-A receptor. Flumazenil is licensed in the United Kingdom and other countries to treat only BZD overdose although numerous studies have demonstrated its effectiveness in rapidly resetting GABA-A receptors, quickly reducing tolerance and dependence from BZD, and providing a safe and rapid detox from benzodiazepines.

Objective

The aim of this article is to provide all healthcare professional who are interested in BZD detoxification with an appr

SUBMITTER: Casari R 

PROVIDER: S-EPMC9008883 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature